141991-17-5Relevant articles and documents
1,3-Diaryl-2-carboxyindoles as potent non-peptide endothelin antagonists
Bunker, Amy M.,Edmunds, Jeremy J.,Berryman, Kent A.,Walker, Donnelle M.,Flynn, Michael A.,Welch, Kathy M.,Doherty, Annette M.
, p. 1061 - 1066 (2007/10/03)
Endothelin-1 is a potent vasoconstrictor that is thought to be involved in many human disease states. We have developed a series of indole non-peptide endothelin antagonists including PD 159110 (31), and ET(A) selective antagonist, and PD 159020 (37), a non-selective ET(A)/ET(B) antagonist. The discovery, synthesis, and structure-activity relationships of this series of compounds are described.