142037-79-4

Basic information

• Product Name: andrographolide
• CAS NO: 142037-79-4
• Molecular Weight: 350.455
• Mol File: 142037-79-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: andrographolide(CAS DataBase Reference)
• NIST Chemistry Reference: andrographolide(142037-79-4)
• EPA Substance Registry System: andrographolide(142037-79-4)

Safety Data

• Hazardous Substances Data: 142037-79-4(Hazardous Substances Data)

Upstream product

• 624-15-7 geraniol 

Downstream Products

• 1609089-34-0 19-O-benzoyl-14-deoxy-14,15-didehydroandrographolide 
• 1609089-43-1 3-O-benzoyl-14-deoxy-14,15-didehydroandrographolide 
• 1609089-36-2 19-O-(2′-carboxybenzoyl)-14-deoxy-14,15-didehydroandrographolide 
• 1609089-56-6 3,19-O-di(2′-carboxybenzoyl)-14-deoxy-14,15-didehydroandrographolide 

Relevant articles and documents

Enantioselective Total Synthesis of Andrographolide and 14-Hydroxy-Colladonin: Carbonyl Reductive Coupling and trans-Decalin Formation by Hydrogen Transfer

An enantioselective total synthesis of the labdane diterpene andrographolide, the bitter principle of the herb Andrographis paniculata (known as “King of Bitters”), was accomplished in 14 steps (LLS). Key transformations include iridium-catalyzed carbonyl reductive coupling to form the quaternary C4 stereocenter, diastereoselective alkene reduction to establish the trans-decalin ring, and carbonylative lactonization to install the α-alkylidene-β-hydroxy-γ-butyrolactone.