1420959-59-6

Basic information

• Product Name: C₁₄H₂₀N₂O₃S
• CAS NO: 1420959-59-6
• Molecular Weight: 296.39
• Mol File: 1420959-59-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 429.0±35.0 °C(Predicted)
• Density: 1.223±0.06 g/cm3(Predicted)
• CAS DataBase Reference: C₁₄H₂₀N₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₂₀N₂O₃S(1420959-59-6)
• EPA Substance Registry System: C₁₄H₂₀N₂O₃S(1420959-59-6)

Safety Data

• Hazardous Substances Data: 1420959-59-6(Hazardous Substances Data)

Upstream product

• 88-13-1 3-Thiophene carboxylic acid 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 59939-74-1 (piperazin-1-yl)(thiophen-3-yl)methanone 

Relevant articles and documents

Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)- 2H-phthalazin-1-ones as potent PARP-1 inhibitors

We have developed a series of substituted 4-(thiophen-2-ylmethyl)-2H- phthalazin-1-ones as potent PARP-1 inhibitors. Preliminary biological evaluation indicated that most compounds possessed inhibitory potencies comparable to, or higher than AZD-2281. Among these compounds, 18q appeared to be the most notable one, which displayed an 8-fold improvement in enzymatic activity compared to AZD-2281. These efforts lay the foundation for our further investigation.