1421227-52-2 Usage
Description
N-(6-4-[(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenylcarbamoyl)amino]phenoxypyrimidin-4-yl)cyclopropanecarboxamide is a complex organic compound with a unique chemical structure. It is characterized by its potential biological activities and applications in various fields, particularly in the pharmaceutical industry.
Uses
1. Used in Pharmaceutical Industry:
N-(6-4-[(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenylcarbamoyl)amino]phenoxypyrimidin-4-yl)cyclopropanecarboxamide is used as a potential therapeutic agent for various medical conditions due to its unique chemical structure and biological activities.
2. Used in Treatment of Diabetes Type I:
N-(6-4-[(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenylcarbamoyl)amino]phenoxypyrimidin-4-yl)cyclopropanecarboxamide is used as a β-cell proliferation inducer via the IκB kinase pathway and modulation of the Erb3 binding-protein. This makes it a potential treatment and cure for diabetes type I, as it may help in the regeneration and maintenance of insulin-producing cells in the pancreas.
3. Used in Drug Delivery Systems:
Similar to gallotannin, N-(6-4-[(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenylcarbamoyl)amino]phenoxypyrimidin-4-yl)cyclopropanecarboxamide may also benefit from novel drug delivery systems to enhance its applications and efficacy against specific medical conditions. Various organic and metallic nanoparticles could be employed as carriers for this compound, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Biological Activity
ws 3 is an agonist of trpm8 receptor with ec50 value of 3.7 μm [1].transient receptor potential cation channel subfamily m member 8 (trpm8) is a ca2+- and na+-permeable ion channel and is activated by cooling agents and cold temperatures. trpm8 belongs to trp family and is expressed in sensory neurons.ws 3 is an agonist of trpm8 receptor and a cooling agent. in hek293 cells expressed recombinant mouse trpm8, ws 3 (30 μm) increased [ca2+]i. ws 3 exhibited potency with ec50 value of 3.7 μm and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. in hek cells stably expressing either htrpm8 or htrpa1, ws 3 activated htrpm8 and htrpa1 with ec50 values of 2.2 and 120.6 μm, respectively. ws 3 was efficacious in eliciting cooling sensation [2].
references
[1]. behrendt hj, germann t, gillen c, et al. characterization of the mouse cold-menthol receptor trpm8 and vanilloid receptor type-1 vr1 using a fluorometric imaging plate reader (flipr) assay. br j pharmacol, 2004, 141(4): 737-745.[2]. klein ah, iodi carstens m, mccluskey ts, et al. novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. chem senses, 2011, 36(7): 649-658.
Check Digit Verification of cas no
The CAS Registry Mumber 1421227-52-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,2,2 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1421227-52:
(9*1)+(8*4)+(7*2)+(6*1)+(5*2)+(4*2)+(3*7)+(2*5)+(1*2)=112
112 % 10 = 2
So 1421227-52-2 is a valid CAS Registry Number.
1421227-52-2Relevant articles and documents
Small-molecule inducer of β cell proliferation identified by high-throughput screening
Shen, Weijun,Tremblay, Matthew S.,Deshmukh, Vishal A.,Wang, Weidong,Filippi, Christophe M.,Harb, George,Zhang, You-Qing,Kamireddy, Anwesh,Baaten, Janine E,Jin, Qihui,Wu, Tom,Swoboda, Jonathan G.,Cho, Charles Y.,Li, Jing,Laffitte, Bryan A.,McNamara, Peter,Glynne, Richard,Wu, Xu,Herman, Ann E.,Schultz, Peter G.
, p. 1669 - 1672 (2013/04/23)
The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based screens using rodent β cell lines to ident
