1421373-71-8

Basic information

• Product Name: EB₁₀₄
• Synonyms: EB₁₀₄
• CAS NO: 1421373-71-8
• Molecular Weight: 497.6
• Mol File: 1421373-71-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: EB₁₀₄(CAS DataBase Reference)
• NIST Chemistry Reference: EB₁₀₄(1421373-71-8)
• EPA Substance Registry System: EB₁₀₄(1421373-71-8)

Safety Data

• Hazardous Substances Data: 1421373-71-8(Hazardous Substances Data)

Upstream product

• 603-76-9 1-methylindole 
• 450-91-9 4-fluoro-2-methoxyaniline 
• 120-72-9 indole 
• 945016-63-7 3-(2-chloro-pyrimidin-4-yl)-1H-indole 
• 1032452-86-0 2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine 
• 1421372-94-2 N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine 
• 1421372-76-0 N-(4-(4-methylpiperazinyl)-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)pyrimidin-2-yl-amine 
• 1421372-75-9 6-methoxy-N¹-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)benzene-1,3-diamine 
• 814-68-6 acryloyl chloride 
• 1075705-01-9 4-fluoro-2-methoxy-5-nitro-phenylamine 

Relevant articles and documents

Refinement of covalent EGFR inhibitor AZD9291 to eliminate off-target activity

Non-small-cell lung cancer (NSCLC) is a major disease that accounts for 85% of all lung cancer cases which claimed around 1.8 billion lives worldwide in 2020. Tyrosine kinase inhibitors (TKIs) that target EGFR have been used for the treatment of NSCLC, but often develop drug resistance, and the covalent inhibitor AZD9291 has been developed to tackle the problem of drug resistance mediated by the T790M EGFR mutation; however, there is a side effect of hyperglycemia that may be due to off-target activity. This study examines analogs of AZD9291 by chemical proteomics, identifying analogs that maintain T790M-EGFR engagement while showing reduced cross-reactivity with off-targets.