1421517-86-3

Basic information

• Product Name: 1-Bromo-4-fluoroisoquinoline
• Synonyms: 1-Bromo-4-fluoroisoquinoline
• CAS NO: 1421517-86-3
• Molecular Formula: C9H5BrFN
• Molecular Weight: 226.0451032
• Mol File: 1421517-86-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Bromo-4-fluoroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-fluoroisoquinoline(1421517-86-3)
• EPA Substance Registry System: 1-Bromo-4-fluoroisoquinoline(1421517-86-3)

Safety Data

• Hazardous Substances Data: 1421517-86-3(Hazardous Substances Data)

Usage

General Description

1-Bromo-4-fluoroisoquinoline is a chemical compound with the molecular formula C9H6BrFN. It is a halogenated isoquinoline derivative, containing a bromine and a fluorine atom on the 1- and 4- positions of the isoquinoline ring, respectively. 1-Bromo-4-fluoroisoquinoline is utilized in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active molecules, including pharmaceutical drugs and agricultural chemicals. Its unique structure and reactivity make it a valuable intermediate in organic synthesis, allowing for the creation of diverse chemical compounds with potential therapeutic and agricultural applications. However, it is important to handle this chemical with care, as it is toxic and poses hazards to human health and the environment.

Upstream product

• 1008-32-8 4--fluoroisoquinoline N--oxide 
• 394-67-2 4--fluoroisoquinoline 
• 1532-71-4 1-bromoisoquinoline 

Downstream Products

• 394-67-2 4--fluoroisoquinoline 

Relevant articles and documents

Synthesis method of 4-fluoroisoquinoline sulfate

The invention discloses a synthesis method of 4-fluoroisoquinoline sulfate, the synthesis method comprises the following steps: S1: putting 1-bromine isoquinoline, an NFSI reagent and acetonitrile into a reaction kettle, sufficiently and uniformly stirring, starting the reaction kettle to enable the reaction temperature to be about 60-65 DEG C, and setting the reaction time to be 6-24 hours; afterthe reaction is finished, spin-drying the organic solvent in the reaction liquid through a vacuum rotary dryer, adding water into the reaction liquid, carrying out water-phase extraction work by using dichloromethane, and combining an organic phase; then adjusting the pH value of the organic phase by using a sodium bicarbonate solution, washing the organic phase by using a sodium chloride solution after the adjustment is finished, and carrying out vacuum spin-drying on the organic phase by using a vacuum rotary dryer so as to synthesize the 1-bromo-4-fluoroisoquinoline. The method is reasonable in design, the preparation steps of the isoquinoline compound can be shortened, the production and synthesis efficiency of the isoquinoline compound can be improved, and then the market requirements are met.