1421676-31-4

Basic information

• Product Name: C₁₃H₉ClF₃N₃O₃
• Synonyms: C₁₃H₉ClF₃N₃O₃
• CAS NO: 1421676-31-4
• Molecular Weight: 347.681
• Mol File: 1421676-31-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₉ClF₃N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₉ClF₃N₃O₃(1421676-31-4)
• EPA Substance Registry System: C₁₃H₉ClF₃N₃O₃(1421676-31-4)

Safety Data

• Hazardous Substances Data: 1421676-31-4(Hazardous Substances Data)

Upstream product

• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 41419-59-4 N-methyl-4-(trifluoromethoxy)aniline 

Relevant articles and documents

Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin- 2-amines as a new class of tubulin polymerization inhibitors

Based on our prior antitumor hits, 32 novel N-alkyl-N-substituted phenylpyridin-2-amine derivatives were designed, synthesized and evaluated for cytotoxic activity against A549, KB, KBVIN, and DU145 human tumor cell lines (HTCL). Subsequently, three new leads (6a, 7g, and 8c) with submicromolar GI50 values of 0.19-0.41 μM in the cellular assays were discovered, and these compounds also significantly inhibited tubulin assembly (IC50 1.4-1.7 μM) and competitively inhibited colchicine binding to tubulin with effects similar to those of the clinical candidate CA-4 in the same assays. These promising results indicate that these tertiary diarylamine derivatives represent a novel class of tubulin polymerization inhibitors targeting the colchicine binding site and showing significant anti-proliferative activity.