1422030-61-2Relevant articles and documents
Asymmetric organocatalytic allylic alkylation of Reissert compounds: A facile access to chiral 1,1-disubstituted 1,2-dihydroisoquinolines
Qin, Tian-You,Liao, Wei-Wei,Zhang, Yan-Jing,Zhang, Sean Xiao-An
, p. 984 - 990 (2013/03/14)
The first asymmetric organocatalytic allylic alkylation of 1,2-dihydro-Reissert compounds and Morita-Baylis-Hillman (MBH) carbonates has been developed, which provided a novel protocol to construct enantioenriched functionalized 1,2-dihydroisoquinolines bearing vicinal quaternary and tertiary chiral centers at C-1 position (up to 94% ee, dr > 20 : 1).