1422275-81-7Relevant articles and documents
Isolation, structure, synthesis and cytotoxicity of an unprecedented flupirtine dimer
Csuk, Rene,Sommerwerk, Sven,Wiese, Jana,Wagner, Christoph,Siewert, Bianka,Kluge, Ralph,Stroehl, Dieter
, p. 1297 - 1304 (2013/02/23)
A previously unknown dimer of the well-established analgesic flupirtine has been found, and its structure was revealed by ESI-MS, NMR spectroscopy and an independent synthesis. Thus, starting from 2-amino-6-chloro-3-nitro-pyridine the target compound was obtained in a four-step synthesis. Key-step of this synthesis is a nickel-mediated aryl-aryl coupling. The dimer 4 did not show any cytotoxicity, and its IC50 values were > 30 μm for all six human cancer cell lines and mouse fibroblasts used in this study.