1422450-71-2

Basic information

• Product Name: 2-[3-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]pyridine
• Synonyms: 2-[3-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]pyridine
• CAS NO: 1422450-71-2
• Molecular Weight: 323.243
• Mol File: 1422450-71-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-[3-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]pyridine(1422450-71-2)
• EPA Substance Registry System: 2-[3-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]pyridine(1422450-71-2)

Safety Data

• Hazardous Substances Data: 1422450-71-2(Hazardous Substances Data)

Upstream product

• 2110-18-1 2-(3-phenylpropyl)pyridine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1422450-63-2 2-[2-benzyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]-pyridine 
• 1422450-64-3 2-benzyl-3-(pyridin-2-yl)propan-1-ol 

Relevant articles and documents

Iridium-Catalyzed Asymmetric Borylation of Unactivated Methylene C(sp3)-H Bonds

Herein, we show the highly enantioselective borylation of unactivated methylene C(sp3)-H bonds in 2-alkylpyridines and 2-alkyl-1,3-azole derivatives using an iridium-BINOL-based chiral monophosphite catalyst system. Quantum chemical calculations using the artificial force induced reaction (AFIR) method suggested that a monophosphite-Ir-tris(boryl) complex generates a narrow chiral reaction pocket where the differentiation of the enantiotopic methylene C-H bonds is accomplished through an assembly of multiple noncovalent interactions.

Iridium-Catalyzed Asymmetric Borylation of Unactivated Methylene C(sp3)-H Bonds

Herein, we show the highly enantioselective borylation of unactivated methylene C(sp3)-H bonds in 2-alkylpyridines and 2-alkyl-1,3-azole derivatives using an iridium-BINOL-based chiral monophosphite catalyst system. Quantum chemical calculations using the artificial force induced reaction (AFIR) method suggested that a monophosphite-Ir-tris(boryl) complex generates a narrow chiral reaction pocket where the differentiation of the enantiotopic methylene C-H bonds is accomplished through an assembly of multiple noncovalent interactions.