142246-63-7

Basic information

• Product Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
• Synonyms: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE;5-FLUORO-DU CEP;5-fluorodeoxyuridine-ce*phosphoramidite for abi;5-FLUORODEOXYURIDINE-CE PHOSPHORAMIDITE FOR CYCLONE;N-blocked-5'-O-DMT CED fluorodeoxyuridine phosphoramidite;5'-DMT-5-F-2'-dU Phosphoramidite
• CAS NO: 142246-63-7
• Molecular Formula: C39H46FN4O8P
• Molecular Weight: 748.78
• Mol File: 142246-63-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Store at -20°C
• CAS DataBase Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(142246-63-7)
• EPA Substance Registry System: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(142246-63-7)

Safety Data

• Hazardous Substances Data: 142246-63-7(Hazardous Substances Data)

Usage

Description

5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE is a nucleoside analog with a complex chemical structure. It is characterized by its 5'-O-(4,4'-dimethoxytrityl) group, which provides stability and protection during chemical synthesis, and a 3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite group, which is essential for the formation of phosphodiester bonds in the synthesis of oligonucleotides. The 5-fluorodeoxyuridine core is a modified nucleoside that has potential applications in various fields due to its unique properties.

Uses

Used in Pharmaceutical Industry:
5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE is used as a building block for the synthesis of oligonucleotides, which are essential in the development of new drugs and therapies. Its application in this field is due to its ability to form stable and protected phosphodiester bonds, which are crucial for the structural integrity and functionality of the synthesized oligonucleotides.
Used in Cancer Research and Treatment:
5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE is used as a potential therapeutic agent for the treatment of breast cancer. It is believed to influence the expression of HER-2, a protein that is overexpressed in certain types of breast cancer cells. By targeting this protein, the compound may help in the development of more effective treatments for breast cancer patients.
Used in Chemical Synthesis and Research:
In the field of chemical synthesis and research, 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE is used as a key intermediate in the synthesis of various nucleoside analogs and modified oligonucleotides. Its unique chemical structure allows for the exploration of new chemical reactions and the development of novel compounds with potential applications in various industries, including pharmaceuticals, diagnostics, and materials science.

Upstream product

• 104495-48-9 1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 50-91-9 5-Fluoro-2'-deoxyuridine 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 

Relevant articles and documents

ON-DEMAND PHOSPHORAMIDITE SYNTHESIS

The invention relates to a method of synthesis of phosphoramidites by immobilization of a phosphitylation agent on a resin activated to create a charged resin, then putting in contact with the charged resin with a suitable substrate. Phosphoramidites are synthesized in a few minutes from the application of the starting materials. Thus, the process makes it possible to create specific phosphoramidites on demand when they are needed in other applications. The substrates to be applied are mainly nucleosides, thus making it possible to create nucleoside phosphoramidites for the subsequent synthesis of oligonucleotides.

Enhancing antitumor efficacy of nucleoside analog 5-fluorodeoxyuridine on her2-overexpressing breast cancer by affibody-engineered DNA nanoparticle

Background: Chemotherapy, as an adjuvant treatment strategy for HER2-positive breast cancer, can effectively improve clinical symptoms and overcome the drug resistance of therapeutic monoclonal antibodies. Nucleoside analogues are a class of traditional c

Floxuridine Homomeric Oligonucleotides “Hitchhike” with Albumin In Situ for Cancer Chemotherapy

Automated attachment of chemotherapeutic drugs to oligonucleotides through phosphoramidite chemistry and DNA synthesis has emerged as a powerful technology in constructing structure-defined and payload-tunable oligonucleotide–drug conjugates. In practice,