1422518-32-8

Basic information

• Product Name: 2-(1-methylpropyl)-5-phenyl-1H-pyrrole
• Synonyms: 2-(1-methylpropyl)-5-phenyl-1H-pyrrole
• CAS NO: 1422518-32-8
• Molecular Weight: 199.296
• Mol File: 1422518-32-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(1-methylpropyl)-5-phenyl-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-methylpropyl)-5-phenyl-1H-pyrrole(1422518-32-8)
• EPA Substance Registry System: 2-(1-methylpropyl)-5-phenyl-1H-pyrrole(1422518-32-8)

Safety Data

• Hazardous Substances Data: 1422518-32-8(Hazardous Substances Data)

Upstream product

• 4379-13-9 (S)-2-amino-3-methylpentanol 
• 98-86-2 acetophenone 
• 98-85-1 1-Phenylethanol 

Relevant articles and documents

NNN-Ruthenium Catalysts for the Synthesis of Pyridines, Quinolines, and Pyrroles by Acceptorless Dehydrogenative Condensation

The bidentate ruthenium complex (HO-C5H3N-CO-C5H3N-C5H4N)Ru(CO)2Cl2 (2) could transform to a tridentate product (HO-C5H3N-CO-C5H3N-C5H4N)Ru(CO)Cl2 (3), which further reacted with CH3ONa in the presence of PPh3 to convert to two complexes [(OC5H3N-CO-C5H3N-C5H4N)Ru(PPh3)2(CO)]Cl- (4) and [(OC5H3N-CO-C5H3N-C5H4N)Ru(PPh3)(CO)Cl] (5), via -OH deprotonation. The catalytic coupling cyclizations of secondary alcohols with amino alcohols were investigated, and complex 3 exhibited the highest activity. The coupling reactions proceeded in air with only 0.2 mol % catalyst loading and had a broad scope for the synthesis of pyridines, quinolones, and pyrroles.

Cobalt-catalyzed acceptorless dehydrogenative coupling of aminoalcohols with alcohols: Direct access to pyrrole, pyridine and pyrazine derivatives

Here, the first example is reported of a new, molecularly defined SNS-cobalt(ii) catalyst for the acceptorless dehydrogenative coupling (ADC) of unprotected amino alcohols with secondary alcohols leading to pyrrole and pyridine derivatives.

The synthesis of pyrroles via acceptorless dehydrogenative condensation of secondary alcohols and 1,2-amino alcohols mediated by a robust and reusable catalyst based on nanometer-sized iridium particles

Pyrroles are important compounds with several applications in medicine and material science. They can be synthesized sustainably from secondary alcohols and amino alcohols. Hydrogen and water are liberated in the course of this reaction. Here, we present that this sustainable catalytic pyrrole synthesis can be mediated efficiently by a novel iridium nanoparticle catalyst. The catalyst synthesis starts from molecular precursors, an N-ligand stabilized Ir complex and a commercially available polysilazane. The generation of nanometer-sized iridium particles was achieved (due to the presence of N atoms in the support). The robust nature of the support allows reuse of the catalyst. The scope of the reaction was verified by the synthesis of 23 pyrrole derivatives (up to 93% isolated yield). Thus, an attractive functional group tolerance (e.g. amines and olefins) could be observed. Commercially available heterogeneous Ir catalysts are inefficient in this pyrrole synthesis and extremely limited in terms of reusability.