1422532-42-0Relevant articles and documents
Synthesis and biological evaluation of a new series of phenothiazine- containing protein farnesyltransferase inhibitors
Abuhaie, Cristina-Maria,Ghinet, Alina,Farce, Amaury,Dubois, Joelle,Gautret, Philippe,Rigo, Benoit,Belei, Dalila,Bicu, Elena
, p. 101 - 110 (2013)
Two new families of human farnesyltransferase inhibitors 13a-m and 14a-d, based on a phenothiazine scaffold, were synthesized. Compounds 14a and 14b were the most promising inhibitors of human farnesyltransferase with IC50 values of 0.7 and 0.6 μM, respectively.