1422841-62-0

Basic information

• Product Name: C₂₆H₂₂N₄O₂
• CAS NO: 1422841-62-0
• Molecular Weight: 422.486
• Mol File: 1422841-62-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₂N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₂N₄O₂(1422841-62-0)
• EPA Substance Registry System: C₂₆H₂₂N₄O₂(1422841-62-0)

Safety Data

• Hazardous Substances Data: 1422841-62-0(Hazardous Substances Data)

Upstream product

• 252199-28-3 4-(benzyloxy)-N-methoxy-N-methylbenzamide 
• 171001-06-2 1-(4-(benzyloxy)phenyl)-2-(pyridin-4-yl)ethanone 
• 1486-51-7 p-(benzyloxy)benzoic acid 
• 79205-04-2 5-methoxy-2-methylquinoline 
• 943656-50-6 C₁₅H₁₃N₃O 
• 1422841-98-2 C₁₁H₁₀BrNO 

Relevant articles and documents

Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A

Twenty eight new analogues were synthesized by optimizing the structure of MP-10 and their in vitro binding affinities towards PDE10A, PDE3A/B, and PDE4A/B were determined. Among these new analogues, 10a, 10b, 10d, 11a, 11b and 11d are very potent towards PDE10A and have IC50 values of 0.40 ± 0.02, 0.28 ± 0.06, 1.82 ± 0.25, 0.24 ± 0.05, 0.36 ± 0.03 and 1.78 ± 0.03 nM respectively; these six compounds displayed high selectivity for PDE10A versus PDE3A/3B/4A/4B. The promising compounds will be further validated in vivo to identify PDE10A imaging tracers. The Royal Society of Chemistry.