142285-64-1

Basic information

• Product Name: 1,6-di-O-benzyl-3,4-O-methylethylidene-D-mannitol
• Synonyms: 1,6-di-O-benzyl-3,4-O-methylethylidene-D-mannitol
• CAS NO: 142285-64-1
• Molecular Weight: 402.488
• Mol File: 142285-64-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,6-di-O-benzyl-3,4-O-methylethylidene-D-mannitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-di-O-benzyl-3,4-O-methylethylidene-D-mannitol(142285-64-1)
• EPA Substance Registry System: 1,6-di-O-benzyl-3,4-O-methylethylidene-D-mannitol(142285-64-1)

Safety Data

• Hazardous Substances Data: 142285-64-1(Hazardous Substances Data)

Upstream product

• 63700-05-0 1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 3969-84-4 3,4-di-O-isopropylidene-D-mannitol 

Downstream Products

• 20258-50-8 1,2,5,6-tetra-O-benzyl-3,4-O-isopropylidene-D-mannitol 
• 226931-87-9 1,6-di-O-benzyl-2,5-di-O-methanesulfonyl-3,4-O-methylethylidene-D-mannitol 
• 628690-07-3 (4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane 

Relevant articles and documents

Highly selective Silver(I) oxide mediated monoprotection of symmetrical diols

Treatment of symmetrical diol with Ag2O and alkyl halide gave the monoprotected derivative in good to excellent yield.

D-mannitol derivatives as HIV aspartyl protease inhibitors

A D-mannitol derivative selected from the group consisting of a compound of formula pharmaceutically acceptable derivatives thereof and where applicable or appropriate pharmaceutically acceptable salts thereof, wherein R1, R2, R3and R4are the same or different and may each independently be selected from among alkyl and aryl (i.e. aromatic including aromatic like) groups. The D-mannitol derivatives may be used as HIV aspartyl protease inhibitors.

Synthesis of C2-symmetrical cyclic guanidino-sugars from D-mannitol

An efficient method for the synthesis of C2-symmetrical cyclic guanidino-sugars has been developed from 1,2:5,6-dianhydro-3,4-O-methylethylidene-D-mannitol or L-iditol.