1422860-71-6

Basic information

• Product Name: 4,4,4-trichloro-3-oxo-2-(phenylhydrazono)butyric acid ethyl ester
• CAS NO: 1422860-71-6
• Molecular Weight: 337.59
• Mol File: 1422860-71-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,4,4-trichloro-3-oxo-2-(phenylhydrazono)butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,4-trichloro-3-oxo-2-(phenylhydrazono)butyric acid ethyl ester(1422860-71-6)
• EPA Substance Registry System: 4,4,4-trichloro-3-oxo-2-(phenylhydrazono)butyric acid ethyl ester(1422860-71-6)

Safety Data

• Hazardous Substances Data: 1422860-71-6(Hazardous Substances Data)

Upstream product

• 3702-98-5 ethyl 4,4,4-trichloroacetoacetate 
• 62-53-3 aniline 

Downstream Products

• 1304779-24-5 (Z)-2-(5-oxo-4-(2-phenylhydrazono)-3-(trichloromethyl)-4,5-dihydro-1H-pyrazol-1-yl)acetohydrazide 
• 1422860-70-5 C₁₀H₇Cl₃N₄O 
• 1304779-36-9 (Z)-1-((5-(4-nitrophenyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)methyl)-4-(phenylhydrazono)-3-(trichloromethyl)-1H-pyrazol-5(4H)-one 
• 1304779-34-7 (Z)-4-(phenylhydrazono)-1-((5-ortho-tolyl-2,3-dihydro-1,3,4-oxadiazol-2-yl)methyl)-3-(trichloromethyl)-1H-pyrazol-5(4H)-one 
• 1304779-33-6 (Z)-1-((5-(4-methoxyphenyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)methyl)-4-(phenylhydrazono)-3-(trichloromethyl)-1H-pyrazol-5(4H)-one 
• 1304779-32-5 (Z)-4-(phenylhydrazono)-1-((5-para-tolyl-2,3-dihydro-1,3,4-oxadiazol-2-yl)methyl)-3-(trichloromethyl)-1H-pyrazol-5(4H)-one 
• 1304779-30-3 (Z)-1-((5-(4-chlorophenyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)methyl)-4-(phenylhydrazono)-3-(trichloromethyl)-1H-pyrazol-5(4H)-one 
• 1304779-28-9 (Z)-1-((5-phenyl-2,3-dihydro-1,3,4-oxadiazol-2-yl)methyl)-4-(phenylhydrazono)-3-(trichloromethyl)-1H-pyrazol-5(4H)-one 

Relevant articles and documents

Microwave-assisted synthesis of 1,3,4-oxadiazoles containing pyrazolones

The key intermediate (Z)-2-(5-oxo-4-(2-phenyl hydrazono )-3-(trichloromethyl)-4,5-dihydro-1H-pyrazole-1-yl)acetohydrazide (5) cyclization with aryl substituted acids 6a-h in presence of phosphorous oxy chloride (POCl3) under microwave irradiation resulted in the formation of the corresponding (Z)-1-((5-phenyl-2,3-dihydro-1,3,4-oxadiazole-2- yl)methyl)-4-(2-substituted aryl hydrazono)-3- (trichloromethyl)-1H-pyrazole- 5(4H)one (7a-h) in quantitative yields. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (5-12 min) and cleaner reactions.