1423136-76-8

Basic information

• Product Name: methyl 4-benzoyl-2-(4-methoxyphenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate
• Synonyms: methyl 4-benzoyl-2-(4-methoxyphenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate
• CAS NO: 1423136-76-8
• Molecular Weight: 458.47
• Mol File: 1423136-76-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 4-benzoyl-2-(4-methoxyphenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-benzoyl-2-(4-methoxyphenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate(1423136-76-8)
• EPA Substance Registry System: methyl 4-benzoyl-2-(4-methoxyphenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate(1423136-76-8)

Safety Data

• Hazardous Substances Data: 1423136-76-8(Hazardous Substances Data)

Upstream product

• 131786-02-2 methyl N-4-nitrobenzylidene-4-methoxyphenylglycinate 
• 3623-15-2 phenyl propargyl ketone 
• 74273-47-5 methyl 2-amino-2-(4-methoxyphenyl)acetate 
• 555-16-8 4-nitrobenzaldehdye 

Relevant articles and documents

Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides to ethynyl ketones

Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to ethynyl ketones catalyzed by the Cu(OAc)2/FOXAP (ferrocenyl oxazolinylphosphine) complex was developed, affording 2,5-dihydropyrrole derivatives in good to excellent yields (up to 99%) and excellent levels of enantioselectivities (up to 98% ee). This highly efficient chiral N,P-ligand/Cu(OAc)2 catalytic system was also applicable for the 1,3-dipolar cycloaddition of α-arylglycine ester-generated azomethine ylides to ynones, affording exclusive quaternary carbon-containing cis-2,5-dihydropyrroles in excellent enantioselectivities (89-92% ee).