142314-69-0

Basic information

• Product Name: Benzoic acid, 2-formyl-5-nitro-, methyl ester
• CAS NO: 142314-69-0
• Molecular Formula: C9H7NO5
• Molecular Weight: 209.158
• Mol File: 142314-69-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-formyl-5-nitro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-formyl-5-nitro-, methyl ester(142314-69-0)
• EPA Substance Registry System: Benzoic acid, 2-formyl-5-nitro-, methyl ester(142314-69-0)

Safety Data

• Hazardous Substances Data: 142314-69-0(Hazardous Substances Data)

Upstream product

• 943-14-6 2-bromo-5-nitrobenzoic acid 
• 7464-91-7 2-formyl-5-nitrobenzoic acid 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 610-93-5 6-nitrophthalide 
• 89891-73-6 6-nitro-3-bromo-3H-isobenzofuran-1-one 
• 77619-93-3 3-hydroxy-6-nitro-1-(3H)isobenzofuranone 
• 198821-81-7 C₁₃H₁₃NO₈ 

Downstream Products

• 101714-14-1 4-nitro-phthalic acid-2-methyl ester 
• 198821-82-8 C₁₂H₁₃NO₆ 

Relevant articles and documents

Synthesis of chiral isoindolinones via asymmetric propargylation/lactamization cascade

A Zn-mediated propargylation/lactamization cascade reaction with chiral 2-formylbenzoate derived N-tert-butanesulfinyl imines was realized, which provided a practical and efficient method for the synthesis of chiral isoindolinones. High diastereoselectivities (up to 97:3 dr) and good reaction yields were observed for most examined cases.

Highly enantioselective synthesis of 2,3-dihydro-1 H-imidazo[2,1-a isoindol-5(9b H)-ones via catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization

Highly enantioselective catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization of N1-alkylethane-1,2-diamine with methyl 2-formylbenzoate catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones with high yields and excellent enantioselectivities. This strategy has been shown to be quite general toward various methyl 2-formylbenzoates.

An indium-mediated allylative/transesterification DFT-directed approach to chiral C(3)-functionalized phthalides

A one-pot synthesis of chiral C(3)-substituted phthalides via an indium-mediated allylation/transesterification reaction is described. The development of this reaction was facilitated through the applied use of DFT calculations to rationalize the stereoselection of a chiral In-mediated process. It was discovered that the enantiomeric excess of this reaction depended upon the steric size, chain length, and substitution of the aldehyde employed.