14235-95-1Relevant articles and documents
TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives
Congiu, Cenzo,Onnis, Valentina,Balboni, Gianfranco,Schiano-Moriello, Aniello,Di Marzo, Vincenzo,De Petrocellis, Luciano
, p. 129 - 138 (2015)
Abstract A series of new 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives was synthesized and evaluated as TRPV1 modulators in a Ca2+ channel assay in HEK-293 cells overexpressing the human recombinant TRPV1 channel. Structura
Preparation of substituted semicarbazides from corresponding amines and hydrazines via phenyl carbamates
Hron, Rebecca,Jursic, Branko S.
supporting information, p. 1540 - 1543 (2014/03/21)
A simple synthetic procedure for the conversion of amines and hydrazines into substituted semicarbazides was developed. The initial condensation between the desired amine and phenyl chloroformate into phenyl carbamate is followed by the addition of hydrazine under basic conditions. The reaction is tolerable to a variety of functional groups, with mild conditions and high percent yields.
A simple method for the preparation of di-, tri- and tetrasubstituted non-symmetrical ureas
Bridgeman, Eve,Tomkinson, Nicholas C. O.
, p. 243 - 246 (2007/10/03)
The synthesis of a series of di-, tri- and tetrasubstituted non-symmetrical ureas is described. Di- and trisubstituted ureas are prepared in excellent yield by treatment of a phenyl carbamate in a self-tunable single-mode microwave synthesizer with a primary or secondary amine. The synthetically more challenging tetrasubstituted urea can be prepared using the 4-nitrophenyl carbamate and a secondary amine. Georg Thieme Verlag Stuttgart.