1423655-72-4

Basic information

• Product Name: 2-(4-phenylpiperazin-1-yl)-4-propyl-pyrimido[4,5-b][1,4]benzothiazine
• CAS NO: 1423655-72-4
• Molecular Weight: 403.551
• Mol File: 1423655-72-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-phenylpiperazin-1-yl)-4-propyl-pyrimido[4,5-b][1,4]benzothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-phenylpiperazin-1-yl)-4-propyl-pyrimido[4,5-b][1,4]benzothiazine(1423655-72-4)
• EPA Substance Registry System: 2-(4-phenylpiperazin-1-yl)-4-propyl-pyrimido[4,5-b][1,4]benzothiazine(1423655-72-4)

Safety Data

• Hazardous Substances Data: 1423655-72-4(Hazardous Substances Data)

Upstream product

• 1423655-62-2 2-[(5-bromo-2-chloro-6-propylpyrimidin-4-yl)sulfanyl]aniline 
• 1373331-49-7 5-bromo-2,4-dichloro-6-propylpyrimidine 
• 16290-54-3 5-bromo-6-propylpyrimidine-2,4(1H,3H)-dione 
• 13345-08-9 6-propyl(1H,3H)pyrimidine-2,4-dione 
• 51-52-5 propylthiouracil 
• 3249-68-1 ethyl butyroyl acetate 

Relevant articles and documents

Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism

A series of 2-substituted 4-n-propyl pyrimido[4,5-b][1,4]benzothiazines were synthesized, and evaluated as soybean 15-lipoxygenase (SLO) inhibitors. Among the synthesized compounds, 2-(4-methyl piperazinyl) analog showed the best SLO inhibition activity (IC50 = 8.9 ± 0.4 μM). To rationalize the inhibitory potency variation of the compounds, computer-assisted modeling of the enzyme-inhibitor, radical scavenging evaluation, and inhibitory mechanism analyses were performed. The results showed that in 4-alkyl pyrimido[4,5-b]benzothiazines with same 2-substituent, radical scavenging potency plays a key role in lipoxygenase inhibition.