142429-13-8

Basic information

• Product Name: Benzeneacetonitrile, a-(1-methoxy-1-methylethoxy)-, (R)-
• CAS NO: 142429-13-8
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol File: 142429-13-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, a-(1-methoxy-1-methylethoxy)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, a-(1-methoxy-1-methylethoxy)-, (R)-(142429-13-8)
• EPA Substance Registry System: Benzeneacetonitrile, a-(1-methoxy-1-methylethoxy)-, (R)-(142429-13-8)

Safety Data

• Hazardous Substances Data: 142429-13-8(Hazardous Substances Data)

Upstream product

• 116-11-0 2-Methoxypropene 
• 10020-96-9 (R)-Mandelonitrile 
• 100-52-7 benzaldehyde 

Downstream Products

• 139163-97-6 L-(-)-N-methyl-3-phenylserine 
• 143771-17-9 (5R)-(+)-4-carbonitrile-3-methyl-5-phenyloxazolidin-2-one 
• 143771-21-5 L-(-)-N-benzyl-3-phenylserine 
• 143771-19-1 ethyl (5R)-(+)-4-carboxylate-3-methyl-5-phenyloxazolidin-2-one 
• 143771-18-0 (4R,5R)-(+)-3-benzyl-4-carbonitrile-5-phenyloxazolidin-2-one 
• 143771-20-4 ethyl (4S,5R)-(+)-3-benzyl-4-carboxylate-5-phenyloxazolidin-2-one 
• 143870-63-7 (3R)-(-)-3-hydroxy-2-methylamino-3-phenylpropionitrile hydrochloride 
• 143870-64-8 (2R,3R)-(-)-2-benzylamino-3-hydroxy-3-phenylpropionitrile hydrochloride 
• 1225375-64-3 methyl (R)-2-(2-(2-methoxypropan-2-yloxy)-2-phenylethylamino)acetate 
• 1225375-65-4 methyl (S)-2({(R)-2-[(2-methoxypropan-2-yl)oxy]-2-phenylethyl}amino)propanoate 
• 1225375-66-5 methyl (S)-2-({(R)-2-[(2-methoxypropan-2-yl)oxy]-2-phenylethyl}amino)-3-phenylpropanoate 
• 1225375-67-6 methyl (S)-2-({(R)-2-[(2-methoxypropan-2-yl)oxy]-2-phenylethyl}amino)pent-4-enoate 
• 14467-49-3 (R)-(-)-α-<<(1-methylethyl)amino>methyl>benzenemethanol 
• 495-42-1 (-)-Halostachine 

Relevant articles and documents

Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

A chemoenzymatic two-step cascade process, with both steps having incompatible reaction conditions, was successfully performed in continuous flow. The chemoenzymatic aqueous formation of cyanohydrins was integrated with a subsequent organic phase protection step in a single flow process utilising a membrane-based phase separation module. The wider applicability of our setup was demonstrated with the synthesis of nine protected cyanohydrin derivatives, all obtained in good yields and high to excellent enantioselectivity.

A one-pot reduction-transimition-reduction synthesis of N-substituted β-ethanolamines from cyanohydrins

An efficient (74% - 97% yield) three-step one-pot synthesis of (R)-Halostachine and analogues from O-protected optically active cyanohydrins is described. The reaction sequence involves a DIBAL reduction of the nitrile to an imine, transimination to a secondary imine and sodium borohydride reduction to the corresponding N-substituted β-ethanolamine. Both O-protected as well as unprotected reaction products can be obtained.