14247-78-0

Basic information

• Product Name: 6-bromo-2-(4-methoxyphenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol
• CAS NO: 14247-78-0
• Molecular Formula: C₁₄H₁₂BrN₃O₂
• Molecular Weight: 334.168
• Mol File: 14247-78-0.mol
• Article Data: 1

Chemical Properties

• Density: 1.612g/cm³
• Refractive Index: 1.686
• CAS DataBase Reference: 6-bromo-2-(4-methoxyphenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-2-(4-methoxyphenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol(14247-78-0)
• EPA Substance Registry System: 6-bromo-2-(4-methoxyphenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol(14247-78-0)

Safety Data

• Hazardous Substances Data: 14247-78-0(Hazardous Substances Data)

Upstream product

• 6307-35-3 2-amino-5-bromo-4-hydroxy-6-methylpyrimidine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 485404-36-2 6-bromo-8-(2-fluoro-benzyl)-2-(4-methoxy-phenyl)-7-methyl-8H-imidazo[1,2-a]pyrimidin-5-one 
• 485404-27-1 2-(4-methoxy-phenyl)-6-(3-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-28-2 2,6-bis-(4-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-32-8 6-(3-fluoro-phenyl)-2-(4-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-26-0 2-(4-methoxy-phenyl)-6-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-30-6 6-(3,4-dimethoxy-phenyl)-2-(4-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-29-3 6-benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-33-9 2-(4-methoxy-phenyl)-7-methyl-6-(3-trifluoromethyl-phenyl)-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-34-0 6-(3,5-dichloro-phenyl)-2-(4-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-31-7 2-(4-methoxy-phenyl)-7-methyl-6-(3,4,5-trimethoxy-phenyl)-imidazo[1,2-a]pyrimidin-5-ol 
• 485404-42-0 8-(2-fluoro-benzyl)-6-(3-fluoro-phenyl)-2-(4-methoxy-phenyl)-7-methyl-8H-imidazo[1,2-a]pyrimidin-5-one 
• 485404-39-5 8-(2-fluoro-benzyl)-2,6-bis-(4-methoxy-phenyl)-7-methyl-8H-imidazo[1,2-a]pyrimidin-5-one 
• 485404-38-4 8-(2-fluoro-benzyl)-2-(4-methoxy-phenyl)-6-(3-methoxy-phenyl)-7-methyl-8H-imidazo[1,2-a]pyrimidin-5-one 
• 485404-37-3 8-(2-fluoro-benzyl)-2-(4-methoxy-phenyl)-6-(2-methoxy-phenyl)-7-methyl-8H-imidazo[1,2-a]pyrimidin-5-one 

Relevant articles and documents

Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

SAR studies of lead GnRH receptor antagonists 2a and 2b reported earlier resulted in the discovery of compound 10b which showed much higher potency (Ki=4.6 nM, compared with 2b, Ki=230 nM) in which the 7-position of the imidazolo[1,2-a]pyrimidone core was substituted with a methyl group, and the ester at the 6-position was replaced by the 3-methoxyphenyl group.