14248-25-0

Basic information

• Product Name: 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester
• Synonyms: 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester
• CAS NO: 14248-25-0
• Molecular Weight: 260.256
• Mol File: 14248-25-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester(14248-25-0)
• EPA Substance Registry System: 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester(14248-25-0)

Safety Data

• Hazardous Substances Data: 14248-25-0(Hazardous Substances Data)

Upstream product

• 547-63-7 Methyl isobutyrate 
• 939-99-1 4-trifluoromethylbenzyl chloride 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 1613145-98-4 3-methyl-1-(8-quinolinyl)-3-(4-(trifluoromethyl)benzyl)-2-azetidinone 
• 1613146-05-6 4-(4-(trifluoromethyl)phenyl)-3,3-dimethyl-1-(8-quinolinyl)-2-azetidinone 
• 1308788-91-1 3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione 
• 1308788-49-9 2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide 
• 1439896-97-5 2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoic acid 
• 14248-28-3 2,2-Dimethyl-3-(p-trifluormethylphenyl)propanol 

Relevant articles and documents

Sulfoximine assisted Pd(II)-catalyzed bromination and chlorination of primary β-C(sp3)-H bond

S-Methyl-S-2-pyridyl-sulfoximine (MPyS) directed bromination and chlorination of the 1°-β-C(sp3)-H bond of MPyS-N-amides is realized under the influence of N-Br/Cl-phthalimides and a Pd(II)-catalyst. The sequential halogenation and acetoxylation of α-dimethyl MPyS-N-amides constructs highly functionalized α-trisubstituted aliphatic acid derivatives. The MPyS directing group is cleaved from the halogenated products and recovered. (Chemical Equation Presented).

Highly regioselective carbonylation of unactivated C(sp3)-H bonds by ruthenium carbonyl

The regioselective carbonylation of unactivated C(sp3)-H bonds of aliphatic amides was achieved using Ru3(CO)12 as a catalyst. The presence of a 2-pyridinylmethylamine moiety in the amide is crucial for a successful reaction. The reaction shows a preference for C-H bonds of methyl groups as opposed to methylene C-H bonds and tolerates a variety of functional groups. The stoichiometric reaction of an amide with Ru 3(CO)12 gave a dinuclear ruthenium complex in which the 2-pyridinylmethylamino moiety was coordinated to the ruthenium center in an N,N manner.