14251-32-2

Basic information

• Product Name: 8-[(2-aminoethyl)amino]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• CAS NO: 14251-32-2
• Molecular Formula: C₉H₁₄N₆O₂
• Molecular Weight: 238.2465
• Mol File: 14251-32-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 492.2°C at 760 mmHg
• Flash Point: 251.5°C
• Density: 1.465g/cm³
• Vapor Pressure: 7.84E-10mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 8-[(2-aminoethyl)amino]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-[(2-aminoethyl)amino]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione(14251-32-2)
• EPA Substance Registry System: 8-[(2-aminoethyl)amino]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione(14251-32-2)

Safety Data

• Hazardous Substances Data: 14251-32-2(Hazardous Substances Data)

Upstream product

• 85-18-7 8-chlorotheophylline 
• 107-15-3 ethylenediamine 

Relevant articles and documents

SMALL MOLECULE BICYCLIC AND TRICYCLIC CFTR CORRECTORS

Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.