142558-69-8Relevant articles and documents
The Chemistry of 5-Oxodihydroisoxazoles. XII. Trapping of Derived Ketenimines with Lithium Amides and Alkyllithiums
Ang, Kiah H.,Prager, Rolf H.,Williams, Craig M.
, p. 55 - 64 (2007/10/02)
Isoxazolones unsubstituted at C 3 react with lithium amides or alkyllithiums to give ketenimines.The presence of an ethoxycarbonyl group at C 4 allows capture of this species by addition of a second equivalent of the lithiated species to give enolates which can be alkylated in situ.The presence of a phenyl group at C 4 gives a ketenimine which reacts intramolecularly in the presence of lithium amides, whereas alkyllithiums undergo addition in synthetically useful processes.
The Chemistry of 5-Oxodihydroisoxazoles. IV. Reactions of Some N-Arylisoxazol-5-ones with Nucleophiles
Ang, Kiah H.,Donati, Cosimo,Donkor, Augustine,Prager, Rolf H.
, p. 2037 - 2048 (2007/10/02)
The reactions of ethyl 2-aryl-5-oxo-2,5-dihydroisoxazole-4-carboxylate (aryl = phenyl, isoquinolin-1-yl, 2-phenylquinazolin-4-yl and 5-nitropyridin-2-yl) with azide and primary, secondary and tertiary amines, and a number of other nucleophiles are describ
