142617-98-9 Usage
Description
1-(4-Fluoro-benzyl)-2-piperazin-1-yl-1H-benzimidazole is a complex chemical compound that features a benzimidazole ring fused with a piperazine moiety. This benzimidazole derivative is characterized by the presence of a fluoro-substituted benzyl group attached to the benzimidazole core and a piperazine side chain. Its intricate structure suggests potential pharmaceutical and therapeutic applications, as it may interact with various biological processes. 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE's ability to modulate central nervous system functions, possibly through effects on neurotransmitter receptors or other neurological targets, positions it as a candidate for further exploration in medicinal chemistry.
Uses
Used in Pharmaceutical Development:
1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE is used as a lead compound for the development of new pharmaceuticals due to its potential to modulate various biological processes. Its complex structure allows for the possibility of affecting a range of targets within the body, making it a promising candidate for the treatment of various diseases and conditions.
Used in Central Nervous System Research:
In the field of neuroscience, 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE is used as a research tool to study the effects of benzimidazole derivatives on neurotransmitter receptors and other neurological targets. Understanding its interactions with these targets can provide insights into the development of drugs for neurological disorders.
Used in Medicinal Chemistry:
1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE serves as a starting point for medicinal chemists to design and synthesize new molecules with improved pharmacological properties. Its unique structure can be modified to enhance its therapeutic potential, selectivity, and safety profile, leading to the creation of more effective drugs.
Further research into the biological activity and pharmacological potential of 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE is necessary to fully understand its properties and unlock its potential uses in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 142617-98-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,6,1 and 7 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 142617-98:
(8*1)+(7*4)+(6*2)+(5*6)+(4*1)+(3*7)+(2*9)+(1*8)=129
129 % 10 = 9
So 142617-98-9 is a valid CAS Registry Number.
142617-98-9Relevant articles and documents
Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds
Tian, Junjun,Vandermosten, Leen,Peigneur, Steve,Moreels, Lien,Rozenski, Jef,Tytgat, Jan,Herdewijn, Piet,Van den Steen, Philippe E.,De Jonghe, Steven
, p. 6332 - 6344 (2017/10/23)
Astemizole is a H1-antagonist endowed with antimalarial activity, but has hERG liabilities. Systematic structural modifications of astemizole led to the discovery of analogues that display very potent activity as inhibitors of the growth of the Plasmodium parasite, but show a decreased hERG inhibition, when compared to astemizole. These compounds can be used as starting point for the development of a new class of antimalarials.
