1426839-89-5Relevant articles and documents
Method for synthesizing and purifying micafungin
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Paragraph 0049-0050, (2017/07/20)
The invention relates to a method for preparing a pharmaceutical intermediate, in particular to a method for synthesizing and purifying a micafungin intermediate. The method comprises the following steps: subjecting a compound II to a carboxylic acid group acylation reaction to obtain a compound III, subjecting the compound III and a compound IV to a condensation reaction, and carrying out crystallization purification to obtain a high-purity micafungin intermediate I. The preparation method provided by the invention has the advantages of simple process, cheap reagents, low solvent consumption, greatly reduced production cost, and higher purity and yield of products, and easy realization in industrial production.
PREPARATION OF MICAFUNGIN INTERMEDIATES
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Page/Page column 40-41, (2013/03/26)
The present invention relates to the preparation of compounds, in particular to the preparation of compounds of formula (I), which may be used with a compound of formula (VI), or a salt thereof as intermediates for the preparation of antifungal agents, pr