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1426959-54-7

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1426959-54-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1426959-54-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,6,9,5 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1426959-54:
(9*1)+(8*4)+(7*2)+(6*6)+(5*9)+(4*5)+(3*9)+(2*5)+(1*4)=197
197 % 10 = 7
So 1426959-54-7 is a valid CAS Registry Number.

1426959-54-7Downstream Products

1426959-54-7Relevant articles and documents

Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors

Zhang, Zhichao,Liu, Chengwu,Li, Xiangqian,Song, Ting,Wu, Zhiyong,Liang, Xiaomeng,Zhao, Yan,Shen, Xiaoyun,Chen, Hongbo

, p. 410 - 420 (2013)

We have previously reported a nanomolar inhibitor of antiapoptotic Mcl-1 protein, 3-thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1). S1 plays its function by binding to the BH3 groove of Mcl-1. Basing on this spacial structural characteristic, we developed a novel class of Mcl-1 inhibitor using fragment-based drug discovery approach. By dissecting S1, we identified the compound 4 with a 2-hydroxypyridine core as the starting fragment. In the following molecular growth, we used the ligand efficiency evaluation and fit quality score to assess the fragments. A novel potent compound, N-benzyl-5-(4-isopropylthiophenol)-2-hydroxyl nicotinamide (12c), which binds Mcl-1 with an IC50 value of 54 nM was obtained. Compound 12c demonstrated a better aqueous solubility than S1.

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