1427272-52-3

Basic information

• Product Name: 6-amino-9-(cyclohexylmethyl)-7H-purin-8(9H)-one
• CAS NO: 1427272-52-3
• Molecular Weight: 247.3
• Mol File: 1427272-52-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-amino-9-(cyclohexylmethyl)-7H-purin-8(9H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-9-(cyclohexylmethyl)-7H-purin-8(9H)-one(1427272-52-3)
• EPA Substance Registry System: 6-amino-9-(cyclohexylmethyl)-7H-purin-8(9H)-one(1427272-52-3)

Safety Data

• Hazardous Substances Data: 1427272-52-3(Hazardous Substances Data)

Upstream product

• 1427272-55-6 8-chloro-9-(cyclohexylmethyl)-9H-purin-6-amine 
• 66224-66-6 adenine 
• 1427272-54-5 9-(cyclohexylmethyl)-8-bromo-9H-purin-6-amine 
• 21149-26-8 8-oxoadenine 
• 2550-36-9 Cyclohexylmethyl bromide 
• 6974-78-3 8-bromoadenine 

Relevant articles and documents

Synthetic strategies to 9-substituted 8-oxoadenines

Three synthetic routes to 9-substituted 8-oxoadenines have been studied: bromination of adenine followed by N-9-alkylation/arylation and finally hydrolysis; bromination of adenine, hydrolysis, and N-functionalization as the last step; and N-9-alkylation of adenine, halogenation, and finally hydrolysis. As long as the N-9-functional group is compatible with conditions required for introduction of the halogen, the latter strategy was the most efficient. Also, a strategy starting from 5-amino-4,6-dichloropyrimidine was found to be a very good alternative for synthesis of 9-substituted 8-oxoadenines. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.