142731-84-8Relevant articles and documents
ISOQUINOLINONE COMPOUND AND USE THEREOF IN PREPARATION OF ANTIVIRAL DRUGS
-
Paragraph 0093; 0094, (2019/06/12)
Disclosed is an isoquinolinone compound as shown in Formula (I) or a stereoisomer, pharmaceutically acceptable salt, solvate or crystal thereof, and a preparation method thereof, and use thereof in the preparation of drugs for treating or preventing viral infectious diseases caused by the hepatitis B virus (HBV) and other viruses, in particular, use thereof in drugs as HBV surface antigen inhibitors and HBV DNA production inhibitors. The compound has a significant activity in inhibiting hepatitis B surface antigen and hepatitis B DNA, and is possible to significantly improve the probability of curing hepatitis B by administration in combination with nucleoside drugs or other drugs in the future, and has good clinical application prospects.
ARYL GLYCOSIDE COMPOUND, PREPARATION METHOD AND USE THEREOF
-
Paragraph 0303-0305, (2014/01/07)
Disclosed are an aryl glycoside compound as represented by formula I or formular I′, a pharmaceutically acceptable salt thereof, optical isomer thereof or a prodrug thereof. The present invention relates to a method of preparing said aryl glycoside compound and the use thereof The aryl glycoside compound of the present invention has an excellent ability on inhibit SGLT activity, especially SGLT2 activity, and is diabetes-fighting medicine with great potential.
Novel lipid A mimetics derived from pentaerythritol: Synthesis and their potent agonistic activity
Jiang, Zi-Hua,Budzynski, Wladyslaw A,Skeels, Lisa N,Krantz, Mark J,Koganty, R.Rao
, p. 8833 - 8842 (2007/10/03)
A pentaerythritol unit is substituted for glucosamine as its functional mimic at the reducing end of lipid A disaccharide. Two such pentaerythritol derived lipid A mimetics 3 and 4, carrying three identical fatty acyl moieties, have been designed and synt