142822-22-8

Basic information

• Product Name: L-pyroglutamyl-L-histidyl-L-trypthophyl-L-seryl-L-tyrosine tert-butyl ester
• Synonyms: L-pyroglutamyl-L-histidyl-L-trypthophyl-L-seryl-L-tyrosine tert-butyl ester
• CAS NO: 142822-22-8
• Molecular Weight: 758.831
• Mol File: 142822-22-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-pyroglutamyl-L-histidyl-L-trypthophyl-L-seryl-L-tyrosine tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-pyroglutamyl-L-histidyl-L-trypthophyl-L-seryl-L-tyrosine tert-butyl ester(142822-22-8)
• EPA Substance Registry System: L-pyroglutamyl-L-histidyl-L-trypthophyl-L-seryl-L-tyrosine tert-butyl ester(142822-22-8)

Safety Data

• Hazardous Substances Data: 142822-22-8(Hazardous Substances Data)

Upstream product

• 20696-57-5 L-tryptophanamide 
• 25575-88-6 L-Pyroglutamyl-L-histidine Methyl Ester 
• 142822-20-6 N-benzyloxycarbonyl-L-seryl-L-tyrosine tert-butyl ester 
• 16874-12-7 Tyr(tBu) 
• 142822-21-7 L-seryl-L-tyrosine tert-butyl ester 
• 33217-51-5 L-pyroglutamyl-L-histidine-L-tryptophane amide 

Downstream Products

• 51871-39-7 L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester 
• 51952-40-0 L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycine amide hydrochloride 
• 52434-75-0 pGlu-His-Trp-Ser-Tyr 

Relevant articles and documents

Expedient Synthesis of Gonadotropin Releasing Hormone (GnRH) Through a Combined Chemical-Enzymatic Approach

We have developed a chemical-enzymatic synthetic approach to gonadotropin releasing hormone Glp1-His2-Trp3-Ser4-Tyr5-Gly6-Leu7-Arg8-Pro9-Gly10-NH2 (GnRH) which enables one to perform the synthesis efficiently according to minimal protection strategy with all reactive side chains of amino acids unprotected.Five peptide bonds His2-Trp3, Tyr5-Gly6, Leu7-Arg8 and Trp3-Ser4, Ser4-Tyr5 were formed by means of α-chymotrypsin and papain, respectively.The remaining four bonds Glp1-His2, Gly6-Leu7, Arg8-Pro9, Pro9-Gly10 were formed by chemical methods.The synthesis is simple to carry out and there are no problems in scaling up as demonstrated by the final coupling on 2 g scale affording highly pure GnRH in the yield of 84-90percent. Key Words: Gonadotropin Releasing Hormone, Enzymatic Peptide Synthesis, Papain, α-Chymotrypsin