1428261-49-7Relevant articles and documents
Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21
Alvarado, Mario,Decara, Juan,Luque, María Jesús,Hernandez-Folgado, Laura,Gómez-Ca?as, María,Gómez-Ruiz, María,Fernández-Ruiz, Javier,Elguero, José,Jagerovic, Nadine,Serrano, Antonia,Goya, Pilar,De Fonseca, Fernando Rodríguez
, p. 1708 - 1716 (2013/05/09)
Searching for novel antiobesity agents, a series of cannabinoid LH21 and of Rimonabant-fatty acid amide analogues have been prepared. Synthesis of pyrazoles 2a-2c was achieved by a two steps simple methodology via α,β-unsaturated ketones. Carboxamides 8a-8h were obtained in good yields from esters 7a-7c by a one-pot procedure which takes place under mild conditions. New compounds have been evaluated in vivo as anorectic agents. Some of them showed interesting properties reducing food intake in rats by a mechanism which does not involve the endocannabinoid system.
