142843-14-9Relevant articles and documents
Inhibitors of Human Renin with C-Termini Derived from Amides and Esters of α-Mercaptoalkanoic Acids
Ashton, Wallace T.,Cantone, Christine L.,Tolman, Richard L.,Greenlee, William J.,Lynch, Robert J.,et al.
, p. 2772 - 2781 (2007/10/02)
New transition-state analogues bearing C-termini derived from α-mercaptoalkanoic acids, esters, and amides were prepared and evaluated as inhibitors of human renin.Addition of α-mercaptoalkanoate esters to a chiral Boc-amino epoxide intermediate led ultim