1428438-97-4

Basic information

• Product Name: C₃₃H₃₇NO₇
• Synonyms: C₃₃H₃₇NO₇
• CAS NO: 1428438-97-4
• Molecular Weight: 559.659
• Mol File: 1428438-97-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₃₇NO₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₃₇NO₇(1428438-97-4)
• EPA Substance Registry System: C₃₃H₃₇NO₇(1428438-97-4)

Safety Data

• Hazardous Substances Data: 1428438-97-4(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 4405-18-9 5-[1,3]dioxolan-2-yl-benzo[1,3]dioxole 
• 1428438-98-5 9-(2-(benzyloxy)-4-formylphenoxy)nonanenitrile 

Downstream Products

• 1428438-65-6 9-(2-(benzyloxy)-4-(7-oxo-7,9-dihydrofuro[3',4':6,7]naphtho[1,2-d][1,3]dioxol-10-yl)phenoxy)nonanenitrile 
• 1428438-66-7 C₂₈H₂₇NO₆ 
• 1428438-67-8 C₃₀H₂₉NO₇ 
• 1428438-58-7 9-(2-(benzyloxy)-4-(7,9-dioxo-7,9-dihydrofuro[3',4':6,7]naphtho[1,2-d][1,3]dioxol-10-yl)phenoxy)nonanenitrile 

Relevant articles and documents

Synthesis and biological evaluation of helioxanthin analogues

Helioxanthin and analogues have been demonstrated to suppress gene expression of human hepatitis B virus. In the continuous attempt to optimize antiviral activity, various structural motifs were grafted on the helioxanthin scaffold. Many such analogues were synthesized and evaluated for their anti-hepatitis B virus activity. Structure-activity relationships of these helioxanthin derivatives are also discussed. Among these new compounds, 15 exhibits the highest activity against HBV (EC50 = 0.06 μM). This compound can suppress viral surface antigen and DNA expression. Furthermore, viral RNA is also diminished while the core promoter is deactivated upon treatment by 15. A plausible working mechanism is postulated. Our results establish helioxanthin lignans as potent anti-HBV agents with unique mode of action. Since their antiviral mechanism is distinct from current nucleoside/nucleotide drugs, helioxanthin lignans constitute a potentially new class of anti-HBV agents for combination therapy.