1428439-34-2

Basic information

• Product Name: C₂₁H₂₄O₆
• Synonyms: C₂₁H₂₄O₆
• CAS NO: 1428439-34-2
• Molecular Weight: 372.418
• Mol File: 1428439-34-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₄O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₄O₆(1428439-34-2)
• EPA Substance Registry System: C₂₁H₂₄O₆(1428439-34-2)

Safety Data

• Hazardous Substances Data: 1428439-34-2(Hazardous Substances Data)

Upstream product

• 569-83-5 xanthohumol 

Relevant articles and documents

Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro

Xanthohumol (1) and xanthohumol D (2) were isolated from spent hops. Isoxanthohumol (3) was obtained from xanthohumol by isomerisation in alkaline solution. Six metabolites were obtained as a result of transformation of xanthohumol (1) by selected fungal cultures. Their structures were established on the basis of their spectral data. One of them: 2″- (2′′′-hydroxyisopropyl)-dihydrofurano-[4″,5″: 3′,4′]-4′,2-dihydroxy-6′-methoxy-α, β-dihydrochalcone (6) has not been previously reported in the literature. The antioxidant properties of hops flavonoids and xanthohumol derivatives were investigated using the 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The effects of these compounds on proliferation of MCF-7, PC-3 and HT-29 human cancer cell lines were determined by the SRB assay. With the exception of one metabolite, all tested compounds showed antiproliferative activity against the tested human cancer lines. α,β- Dihydroxanthohumol (4), obtained through the biotransformation of xanthohumol, showed higher antiproliferative activity against MCF-7 human breast carcinoma cell line than cisplatin, a widely used anticancer therapeutic agent, and a comparably high activity against PC-3 human prostate cancer cell line.