1428536-62-2Relevant articles and documents
Synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems via intramolecular Friedel-Crafts cyclization
Kargbo, Robert B.,Sajjadi-Hashemi, Zohreh,Roy, Sujata,Jin, Xiaomin,Herr, R. Jason
, p. 2018 - 2021 (2013/04/10)
The intramolecular Friedel-Crafts cyclization was found to be effective for the synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems using simple allylic bromides tethered to activated aromatic nuclei. Amongst the various Lewis acids screened, Bi(OTf)3 was found to be the most effective 'ecofriendly' catalyst for the cyclization.