14289-44-2

Basic information

• Product Name: 2-Naphthylglycolic acid
• Synonyms: 2-Naphthylglycolic acid
• CAS NO: 14289-44-2
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.206
• Mol File: 14289-44-2.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Naphthylglycolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthylglycolic acid(14289-44-2)
• EPA Substance Registry System: 2-Naphthylglycolic acid(14289-44-2)

Safety Data

• Hazardous Substances Data: 14289-44-2(Hazardous Substances Data)

Upstream product

• 13651-05-3 2,2-dibromo-1-(naphthalen-2-yl)ethan-1-one 
• 91-20-3 naphthalene 
• 75-36-5 acetyl chloride 
• 91395-22-1 2,2-dichloro-1-(naphthalen-2-yl)ethan-1-one 
• 14289-45-3 2-(naphthalen-2-yl)-2-oxoacetic acid 
• 93-08-3 methyl 2-naphthyl ketone 
• 56-37-1 N-benzyl-N,N,N-triethylammonium chloride 
• 620-23-5 m-tolyl aldehyde 
• 66-99-9 β-naphthaldehyde 
• 139224-73-0 2-(naphthalen-2-yl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 67-66-3 chloroform 
• 1504663-42-6 C₁₉H₂₀OSi 
• 124-38-9 carbon dioxide 
• 1504663-25-5 [dimethylphenylsilyl(naphthalen-2-yl)methoxy]trimethylsilane 

Downstream Products

• 1592-38-7 2-Naphthalenemethanol 
• 43210-73-7 (R)-2-hydroxy-2-(2-naphthyl)acetic acid 
• 144371-23-3 (S)-2-hydroxy-2-(naphthalen-2-yl)acetic acid 
• 1158519-57-3 C₁₉H₁₄F₃NO₂ 
• 887641-54-5 C₁₉H₁₆O₃ 

Relevant articles and documents

Mono-β-cyclodextrin as an Efficient Glyoxalase Mimic

Trifunctional mono-β-cyclodextrin (MACD) has been prepared and used as a gloxalase model.When 2-naphthylglyoxal (NAGO) is employed as a diagnostic substrate, MACD shows an overall activity greater than the reference compo

Photocatalytic Carbinol Cation/Anion Umpolung: Direct Addition of Aromatic Aldehydes and Ketones to Carbon Dioxide

We have developed a new photocatalytic umpolung reaction of carbonyl compounds to generate anionic carbinol synthons. Aromatic aldehydes or ketones reacted with carbon dioxide in the presence of an iridium photocatalyst and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzimidazole (DMBI) as a reductant under visible-light irradiation to furnish the corresponding α-hydroxycarboxylic acids through nucleophilic addition of the resulting carbinol anions to electrophilic carbon dioxide.

The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).

Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations

Inhibition of group IIA secreted phospholipase A2 (GIIA sPLA2) has been an important objective for medicinal chemists. We have previously shown that inhibitors incorporating the 2-oxoamide functionality may inhibit human and mouse GIIA sPLA2s. Herein, the development of new potent inhibitors by molecular docking calculations using the structure of the known inhibitor 7 as scaffold, are described. Synthesis and biological evaluation of the new compounds revealed that the long chain 2-oxoamide based on (S)-valine GK241 led to improved activity (IC50 = 143 nM and 68 nM against human and mouse GIIA sPLA2, respectively). In addition, molecular dynamics simulations were employed to shed light on GK241 potent and selective inhibitory activity.