1428946-52-4 Usage
Structure
Modified vitamin D3
The addition of a methylene group at the C2 position.
Biological Activity
Enhanced compared to natural vitamin D3
The modification increases its potency in the body.
Receptor Interaction
Potent agonist of the vitamin D receptor
It effectively binds to and activates the vitamin D receptor.
It helps improve bone density and strength.
Anti-Cancer Properties
Inhibiting cell proliferation and inducing differentiation in certain cancer cell lines
It has the potential to slow down or stop the growth of cancer cells and encourage them to become normal cells.
Therapeutic Potential
Treatment of various diseases, including osteoporosis and certain types of cancer
The modified vitamin D3 analog has shown promise in treating a range of health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1428946-52-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,8,9,4 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1428946-52:
(9*1)+(8*4)+(7*2)+(6*8)+(5*9)+(4*4)+(3*6)+(2*5)+(1*2)=194
194 % 10 = 4
So 1428946-52-4 is a valid CAS Registry Number.
1428946-52-4Relevant articles and documents
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-METHYLENE ANALOGS OF CALCITRIOL AND RELATED COMPOUNDS
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, (2017/02/28)
Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D3, (20S)-1α-hydroxy-2-m
2-methylene-vitamin D analogs and their uses
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Page/Page column 15; 19; 20, (2013/04/13)
This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-1α,25 -dihydroxy-2-methylene-vitamin D3 as well as (5E)-(20S)-1α,25-dihydroxy-2 -methylene-vitamin D3 and (20R)-1α,25-dihydroxy-2-methylene-vitamin D
