1428989-73-4Relevant articles and documents
Synthesis, characterization, and cytotoxicity of platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine
Li, Luwei,Zhang, Jinchao,Ma, Lili,Zhang, Zhilei,Wang, Shuxiang,Li, Shenghui,Zhou, Guoqiang
, p. 638 - 649 (2013/05/22)
Eight new platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L- amino acid dianion and diimine/diamine ligands, [Pd(en)(Tsile)]·H 2O (1), [Pd(bipy)(Tsile)] (2), [Pd(bipy)(Tsthr)]·0.5H 2O (3), [Pd(phen)(Tsile)]·0.5H2O (4), [Pd(phen)(Tsthr)]·H2O (5), [Pd(bqu)(Tsthr)]·1.5H 2O (6), [Pt(en)(Tsser)] (7), and [Pt(en)(Tsphe)]·H 2O (8), have been synthesized and characterized by elemental analyses, 1H NMR and mass spectrometry. The crystal structure of 7 has been determined by X-ray diffraction. Cytotoxicities were tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and sulforhodamine B assays. The complexes exert cytotoxicity against HL-60, Bel-7402, BGC-823, and KB cell lines with 4 having the best cytotoxicity against HL-60, Bel-7402, and BGC-823 cell lines; the compounds are less cytotoxic than cisplatin.