1429124-23-1

Basic information

• Product Name: C₁₄H₅Cl₃N₂S
• Synonyms: C₁₄H₅Cl₃N₂S
• CAS NO: 1429124-23-1
• Molecular Weight: 339.632
• Mol File: 1429124-23-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₅Cl₃N₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₅Cl₃N₂S(1429124-23-1)
• EPA Substance Registry System: C₁₄H₅Cl₃N₂S(1429124-23-1)

Safety Data

• Hazardous Substances Data: 1429124-23-1(Hazardous Substances Data)

Upstream product

• 1897-45-6 chlorothalonil 
• 108-98-5 thiophenol 

Relevant articles and documents

Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives

A series of polyhalo isophthalonitrile derivatives (3 and 4) that incorporate a variety of substituents at the 2-, 4-, 5- and/or 6-positions of the isophthalonitrile moieties have been designed and synthesized. These derivatives were evaluated for their antimicrobial activity against Staphylococcus aureus, Bacillus cereus (Gram-positive bacteria), Escherichia coli, Pseudomonas aeruginosa (Gram-negative bacteria); and Candida albicans (Fungi). Compounds 3 and 4 showed stronger inhibition of Gram-positive bacteria and fungi growth, and the antimicrobial ability of compound 3j (a 4-(benzylamino)-5-chloro-2,6-difluoro analog, MIC[SA] = 0.5 μg/mL; MIC[BC] = 0.4 μg/mL; MIC[CA] = 0.5 μg/mL) were close to nofloxacin and fluconazole and identified as the most potent antimicrobial agents in the series. The preliminary analysis of structure-activity relationships is also discussed.