1429297-50-6

Basic information

• Product Name: C₁₆H₁₄Cl₂FNO₄
• Synonyms: C₁₆H₁₄Cl₂FNO₄
• CAS NO: 1429297-50-6
• Molecular Weight: 374.196
• Mol File: 1429297-50-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₄Cl₂FNO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₄Cl₂FNO₄(1429297-50-6)
• EPA Substance Registry System: C₁₆H₁₄Cl₂FNO₄(1429297-50-6)

Safety Data

• Hazardous Substances Data: 1429297-50-6(Hazardous Substances Data)

Upstream product

• 1429297-51-7 C₁₅H₁₅NO₄ 
• 54916-66-4 5-bromo-2-methoxy-nicotinic acid 
• 877397-65-4 (S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol 
• 142063-12-5 methyl 5-hydroxy-2-methoxypyridinecarboxylate 

Downstream Products

• 1429297-57-3 C₂₃H₁₉Cl₂FN₄O₃ 
• 1429297-58-4 C₂₆H₂₆Cl₂FN₅O₃ 
• 1429297-59-5 C₂₈H₂₈Cl₂FN₅O₄ 
• 1429297-24-4 C₂₂H₁₇Cl₂FN₄O₃ 
• 1429297-25-5 C₂₅H₂₄Cl₂FN₅O₃ 
• 1429297-26-6 C₂₇H₂₆Cl₂FN₅O₄ 
• 1429297-49-3 C₁₅H₁₂Cl₂FNO₄ 
• 1429297-27-7 C₂₁H₁₇Cl₂FN₂O₃ 
• 1429297-28-8 C₂₆H₂₇Cl₂FN₄O₃ 
• 1429297-29-9 C₂₅H₂₆Cl₂FN₅O₃ 
• 1429297-30-2 C₂₄H₂₃Cl₂FN₄O₄ 
• 1429297-31-3 C₂₈H₃₁Cl₂FN₄O₄ 
• 1429297-32-4 C₂₇H₂₉Cl₂FN₄O₃ 
• 1429297-33-5 C₂₈H₂₈Cl₂F₄N₄O₃ 

Relevant articles and documents

Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors

A series of novel 5-(benzyloxy)pyridin-2(1H)-ones were designed, synthesized and biologically evaluated for c-Met inhibition. Various amides and benzoimidazoles at C-3 position were investigated. A potent compound 12b with a c-Met IC50 of 12 nM was identified. This compound exhibited potent inhibition of EBC-1 cell associated with c-Met constitutive activation and showed high selectivity for c-Met than other tested 11 kinases. The binding model 12b with c-Met was disclosed by docking analysis.