1429471-01-1Relevant articles and documents
Total synthesis of pipecolic acid and 1-: C -alkyl 1,5-iminopentitol derivatives by way of stereoselective aldol reactions from (S)-isoserinal
Ba?, Sebastian,Kusy, Rafa?,Pasternak-Suder, Monika,Nicolas, Cyril,Mlynarski, Jacek,Martin, Olivier R.
, p. 1118 - 1125 (2018/02/21)
A short synthesis of iminosugars and pipecolic acid derivatives has been realized through aldol addition of a pyruvate, a range of ketones and (S)-isoserinal, followed by catalytic reductive intramolecular amination. The stereoselective aldol reaction was achieved successfully by using tertiary amines or di-zinc aldol catalysts, thus constituting two parallel routes to optically pure products with good yields and high diastereo-selectivities. These carbohydrate analogues may be the inhibitors of potent glycosidases and glycosyltransferases.