142952-69-0

Basic information

• Product Name: 2-(6-amino-9H-purin-9-yl)-1,4-anhydro-2,3-dideoxy-1-thio-L-threo-pentitol
• CAS NO: 142952-69-0
• Molecular Formula: C₁₀H₁₃N₅OS
• Molecular Weight: 251.3081
• Mol File: 142952-69-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 565°C at 760 mmHg
• Flash Point: 295.5°C
• Density: 1.77g/cm³
• Vapor Pressure: 1.32E-13mmHg at 25°C
• Refractive Index: 1.876
• CAS DataBase Reference: 2-(6-amino-9H-purin-9-yl)-1,4-anhydro-2,3-dideoxy-1-thio-L-threo-pentitol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-amino-9H-purin-9-yl)-1,4-anhydro-2,3-dideoxy-1-thio-L-threo-pentitol(142952-69-0)
• EPA Substance Registry System: 2-(6-amino-9H-purin-9-yl)-1,4-anhydro-2,3-dideoxy-1-thio-L-threo-pentitol(142952-69-0)

Safety Data

• Hazardous Substances Data: 142952-69-0(Hazardous Substances Data)

Usage

Type

Chemical compound.

Activity

Potent antiviral and antitumor agent.

Mechanism of action

Inhibits S-adenosylhomocysteine (AdoHcy) hydrolase.

Effective against

Herpes simplex virus, human immunodeficiency virus (HIV), and hepatitis B virus.

Anticancer potential

Promising, particularly in the treatment of leukemia and other types of cancer.

Research status

Ongoing, with the aim of developing it into a valuable therapeutic agent for viral infections and cancer.

Upstream product

• 142941-55-7 (3'R,5'R)-1-<5'-<(benzyloxy)methyl>tetrahydro-3'-thienyl>-9H-purin-6-amine 
• 204509-29-5 6-amino-9-[(3R,5R)-5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydrothiophen-3-yl]purine 
• 109905-51-3 (2S,4S)-1,2:4,5-dianhydro-3-deoxypentitol 
• 204508-96-3 (3S,5R)-5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydrothiophene-3-ol 
• 204508-98-5 (3S,5R)-5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-[(methylsulfonyl)oxy]tetrahydrothiophene 
• 591-93-5 1,4-Pentadiene 
• 92691-36-6 (2S,4S)-pentane-1,2,3,4-tetraol 
• 136030-29-0 (2S,4S)-1,5-dichloro-2,4-pentanediol 
• 204508-90-7 (3S,5R)-5-(hydroxymethyl)tetrahydrothiophene-3-ol 
• 132813-61-7 (3R,5S)-5-Benzyloxymethyl-2-methoxy-tetrahydro-furan-3-ol 
• 142941-51-3 (2R,4S)-2-<(benzyloxy)methyl>-4-<(methylsulfonyl)oxy>tetrahydrothiophene 
• 142941-49-9 (2R,4S)-2-benzoyloxy-5-(benzyloxy)pentane-1,4-diol 
• 132813-67-3 (2R,4S)-4-benzoyloxy-2-<(benzyloxy)methyl>tetrahydrothiophene 
• 142941-46-6 methyl 2-O-benzoyl-5-O-benzyl-3-deoxy-D-erythropentofuranoside 

Relevant articles and documents

Synthesis and testing of new modified nucleosides

New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-c and the L-2',3'-dideoxy isonucleosides 2abc (both the oxa and thia analogues) as well as new routes for the preparation of L-ribose and 2-deoxy L-ribose 3ab and their modified nucleosides 4.

Enantiospecific Synthesis of 3'-Hetero-dideoxy Nucleoside Analogues as Potential Anti-HIV Agents

Two series of analogues of 2',3'-dideoxy carbocyclic nucleosides, in which the 3'-carbon atom is replaced by either an oxygen or a sulfur atom, have been prepared enantiospecifically from diacetone-L-glucose and diacetone-D-glucose respectively.Within eac