1429642-76-1

Basic information

• Product Name: 1-(2-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-benzo[d]imidazole-2-thiol
• Synonyms: 1-(2-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-benzo[d]imidazole-2-thiol
• CAS NO: 1429642-76-1
• Molecular Weight: 338.476
• Mol File: 1429642-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-benzo[d]imidazole-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-benzo[d]imidazole-2-thiol(1429642-76-1)
• EPA Substance Registry System: 1-(2-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-benzo[d]imidazole-2-thiol(1429642-76-1)

Safety Data

• Hazardous Substances Data: 1429642-76-1(Hazardous Substances Data)

Upstream product

• 1429642-70-5 2-((4-methylpiperazin-1-yl)methyl)-N-(2-nitrophenyl)aniline 
• 19577-84-5 2-((4-methylpiperazin-1-yl)methyl)aniline 
• 19577-82-3 1-methyl-4-[(2-nitrophenyl)methyl]piperazine 
• 109-01-3 1-methyl-piperazine 
• 552-89-6 2-nitro-benzaldehyde 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 1401791-44-3 (S)-N-(2-chloro-4-methylphenyl)-2-((1-(2-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 
• 1401791-45-4 (R)-N-(2-chloro-4-methylphenyl)-2-((1-(2-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-benzo[d]imidazol-2-yl)thio)propanamide 

Relevant articles and documents

Asymmetric synthesis of host-directed inhibitors of myxoviruses

High-throughput screening (HTS) previously identified benzimidazole 1 (JMN3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. In pursuit of a lead compound from this series for development, we sought to increase both the potency and the aqueous solubility of 1. Lead optimization has achieved compounds with potent antiviral activity against a panel of myxovirus family members (EC50 values in the low nanomolar range) and much improved aqueous solubilities relative to that of 1. Additionally, we have devised a robust synthetic strategy for preparing 1 and congeners in an enantio-enriched fashion, which has allowed us to demonstrate that the (S)-enantiomers are generally 7- to 110-fold more potent than the corresponding (R)-isomers.