1429766-01-7Relevant articles and documents
Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor
He, Yulong,Dou, Huixia,Gao, Dingding,Wang, Ting,Zhang, Mingming,Wang, Heyao,Li, Yingxia
, (2019)
Fatty acid binding protein 4 (FABP4) and fatty acid binding protein 5 (FABP5) are mainly expressed in adipocytes and/or macrophages and play essential roles in energy metabolism and inflammation. When FABP4 function is diminished, FABP5 expression is high
SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
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Page/Page column 131, (2013/04/24)
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.