1430074-74-0Relevant articles and documents
Diiodine-Mediated Oxidative Reaction for the Construction of Imidazo[1,5- a ]pyridines under Metal-Free Conditions
Chen, Baohua,Chen, Yongxin,Liu, Yafeng,Qin, Mingda,Su, Kexin,Tian, Yuan
supporting information, p. 695 - 698 (2020/04/08)
An efficient and general protocol has been developed for preparing imidazo[1,5- a ]pyridines in moderate to excellent yields by an I 2 -mediated sequential dual oxidative C(sp 3)-H amination of ethyl pyridin-2-ylacetates with benzylamines. The metal- and peroxide-free reaction involves oxidative dehydrogenation and two C-N couplings.
Metal-free synthesis of imidazo[1,5- a] pyridines via elemental sulfur mediated sequential dual oxidative Csp3-H amination
Sheng, Jie,Liu, Jidan,Zhao, He,Zheng, Liyao,Wei, Xingchuan
supporting information, p. 5570 - 5574 (2018/08/17)
A simple and efficient approach has been developed for the synthesis of imidazo[1,5-a]pyridines using the elemental sulfur mediated sequential dual oxidative Csp3-H amination of 2-pyridyl acetates and amines under metal- and peroxide-free conditions. Broad substrate scope, operational simplicity and gram-scale ability make this chemistry very practical.
Rhodium-catalyzed NH insertion of pyridyl carbenes derived from pyridotriazoles: A general and efficient approach to 2-picolylamines and imidazo[1,5-a]pyridines
Shi, Yi,Gulevich, Anton V.,Gevorgyan, Vladimir
, p. 14191 - 14195 (2015/01/09)
A general and efficient NH insertion reaction of rhodium pyridyl carbenes derived from pyridotriazoles was developed. Various NH-containing compounds, including amides, anilines, enamines, and aliphatic amines, smoothly underwent the NH insertion reaction to afford 2-picolylamine derivatives. The developed transformation was further utilized in a facile one-pot synthesis of imidazo[1,5-a]pyridines.
