1430229-98-3

Basic information

• Product Name: C₂₁H₁₅BrClN₃O₄
• CAS NO: 1430229-98-3
• Molecular Weight: 488.725
• Mol File: 1430229-98-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₅BrClN₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₅BrClN₃O₄(1430229-98-3)
• EPA Substance Registry System: C₂₁H₁₅BrClN₃O₄(1430229-98-3)

Safety Data

• Hazardous Substances Data: 1430229-98-3(Hazardous Substances Data)

Upstream product

• 192810-12-1 3-bromo-5-hydroxy-benzoic acid methyl ester 
• 454-16-0 1-fluoro-2-methoxy-4-nitrobenzene 
• 2775-87-3 3-N-benzoyluracil 

Relevant articles and documents

Crystal structures of HIV-1 reverse transcriptase with picomolar inhibitors reveal key interactions for drug design

X-ray crystal structures at 2.9 ? resolution are reported for two complexes of catechol diethers with HIV-1 reverse transcriptase. The results help elucidate the structural origins of the extreme antiviral activity of the compounds. The possibility of halogen bonding between the inhibitors and Pro95 is addressed. Structural analysis reveals key interactions with conserved residues P95 and W229 of importance for design of inhibitors with high potency and favorable resistance profiles.