1430340-78-5

Basic information

• Product Name: C₂₂H₂₅F₄N₃O
• Synonyms: C₂₂H₂₅F₄N₃O
• CAS NO: 1430340-78-5
• Molecular Weight: 423.454
• Mol File: 1430340-78-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₅F₄N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₅F₄N₃O(1430340-78-5)
• EPA Substance Registry System: C₂₂H₂₅F₄N₃O(1430340-78-5)

Safety Data

• Hazardous Substances Data: 1430340-78-5(Hazardous Substances Data)

Upstream product

• 1430341-32-4 (2-fluoro-4-[trifluoromethyl]phenyl)(pyridin-3-yl)methanol 
• 89763-93-9 2-Fluoro-4-(trifluoromethyl)benzaldehyde 
• 626-55-1 3-Bromopyridine 
• 1430341-33-5 3-(chloro[2-fluoro-4-(trifluoromethyl)phenyl]methyl)pyridine 
• 155295-47-9 2,2-dimethyl-1-(piperazin-1-yl)propan-1-one 

Relevant articles and documents

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

A scaffold hopping exercise undertaken to expand the structural diversity of the fenarimol series of anti-Trypanosoma cruzi (T. cruzi) compounds led to preparation of simple 1-[phenyl(pyridin-3-yl)methyl]piperazinyl analogues of fenarimol which were investigated for their ability to inhibit T. cruzi in vitro in a whole organism assay. A range of compounds bearing amide, sulfonamide, carbamate/carbonate and aryl moieties exhibited low nM activities and two analogues were further studied for in vivo efficacy in a mouse model of T. cruzi infection. One compound, the citrate salt of 37, was efficacious in a mouse model of acute T. cruzi infection after once daily oral dosing at 20, 50 and 100 mg/kg for 5 days.