1430400-18-2

Basic information

• Product Name: 1-methoxy-2-(4-chlorophenyl)brassinin
• Synonyms: 1-methoxy-2-(4-chlorophenyl)brassinin
• CAS NO: 1430400-18-2
• Molecular Weight: 376.931
• Mol File: 1430400-18-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methoxy-2-(4-chlorophenyl)brassinin(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methoxy-2-(4-chlorophenyl)brassinin(1430400-18-2)
• EPA Substance Registry System: 1-methoxy-2-(4-chlorophenyl)brassinin(1430400-18-2)

Safety Data

• Hazardous Substances Data: 1430400-18-2(Hazardous Substances Data)

Upstream product

• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 105748-60-5 1-methoxybrassinin 

Relevant articles and documents

Spirocyclisation of phytoalexin 1-methoxybrassinin in the presence of Grignard reagents

The anti-cancer properties of naturally occurring (2R, 3R)-(-)-1- methoxyspirobrassinol methyl ether (I) and their synthetic amino or piperidyl analogues II inspired us to study the synthesis of new target compounds III with a C - C bond in the 2-position of indole rather than a C - N or C - O bond (I or II respectively). The goal was achieved via electrophilic-nucleophilic 3,2-difunctionalisation of 1-methoxybrassinin (IV) in the presence of bromine and the Grignard reagent leading to the formation of cis- and trans-C - C analogues of I. Finally, the anti-cancer activities of the new compounds were measured and compared with I and II in order to show the importance of a heteroatom in the 2-substituted indole on the anti-cancer activity of spirobrassinols.