14305-31-8

Basic information

• Product Name: α-acetyl-4-methylbenzenepropanoic acid ethyl ester
• Synonyms: α-acetyl-4-methylbenzenepropanoic acid ethyl ester
• CAS NO: 14305-31-8
• Molecular Weight: 234.295
• Mol File: 14305-31-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: α-acetyl-4-methylbenzenepropanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: α-acetyl-4-methylbenzenepropanoic acid ethyl ester(14305-31-8)
• EPA Substance Registry System: α-acetyl-4-methylbenzenepropanoic acid ethyl ester(14305-31-8)

Safety Data

• Hazardous Substances Data: 14305-31-8(Hazardous Substances Data)

Usage

General Description

α-acetyl-4-methylbenzenepropanoic acid ethyl ester is a chemical compound with the molecular formula C12H16O3. It is an ester, a derivative of a carboxylic acid in which the hydrogen of the hydroxyl group is replaced by an alkyl or aryl group. This particular compound is notable for its acetyl and methyl substituents, giving it specific properties and potential applications. It is commonly used in the synthesis of pharmaceuticals and perfumes, as well as in organic chemistry research.α-acetyl-4-methylbenzenepropanoic acid ethyl ester may also have potential industrial uses, particularly in the creation of diverse products such as fragrances, flavorings, and other specialty chemicals.

Upstream product

• 141-97-9 ethyl acetoacetate 
• 104-82-5 4-Methylbenzyl chloride 
• 104-81-4 4-Methylbenzyl bromide 
• 6186-89-6 ethyl methyl malonate 

Downstream Products

• 1091602-25-3 C₁₈H₂₁N₃O₄S 
• 109471-39-8 3-methyl-4-(4-methylbenzyl)-1-phenyl-1,4-dihydro-5H-pyrazol-5-one 
• 95314-43-5 C₂₀H₂₁N₃O₉ 
• 1285559-86-5 ethyl 3-(p-tolyl)pyruvate phenyl hydrazone 
• 30015-86-2 3-(4-methylphenyl)-1H-indole 
• 1285560-13-5 1-benzyl-5-[3-(4-methyl-phenyl)indol-2-yl]pyrrolidin-2-one 
• 1266898-24-1 3-(p-tolyl)-1H-indole-2-carboxylic acid 
• 866155-18-2 ethyl 3-(p-tolyl)-1H-indole-2-carboxylate 
• 14248-36-3 2-methyl-4-(p-tolyl)butan-2-ol 
• 14276-95-0 1,1,6-trimethylindan 
• 61971-92-4 1-isopentyl-4-methylbenzene 
• 95314-44-6 C₂₀H₂₀N₃O₉^(1-)*C₆H₁₅N*H⁽¹⁺⁾ 

Relevant articles and documents

Discovery of remogliflozin etabonate: A potent and highly selective SGLT2 inhibitor

We optimized the structure of an active metabolite (1) of WAY-123783, which was obtained from mouse urine after oral administration, to improve selectivity for SGLT2 and oral bioavailability. O-glucoside derivative 24 (remogliflozin etabonate) was subsequently identified as a potent, highly selective, and orally available SGLT2 inhibitor.

Tunable Aerobic Oxidative Hydroxylation/Dehydrogenative Homocoupling of Pyrazol-5-ones under Transition-Metal-Free Conditions

A practical and tunable transition-metal-free aerobic oxidation of pyrazol-5-ones preparing either 4-hydroxypyrazoles (via C-H hydroxylation) or bispyrazoles (via dehydrogenative homocoupling) is described. The K2CO3/dioxane reagent system predominately promoted hydroxylation to deliver the α-hydroxylated pyrazoles. In contrast, the formation of bispyrazoles was overwhelmingly preferred with CH3CN as the reaction medium without any additives.

gem-Difluoroolefination of Diazo Compounds with TMSCF3 or TMSCF2Br: Transition-Metal-Free Cross-Coupling of Two Carbene Precursors

A new olefination protocol for transition-metal-free cross-coupling of two carbene fragments arising from two different sources, namely, a nonfluorinated carbene fragment resulting from a diazo compound and a difluorocarbene fragment derived from Ruppert-Prakash reagent (TMSCF3) or TMSCF2Br, has been developed. This gem-difluoroolefination proceeds through the direct nucleophilic addition of diazo compounds to difluorocarbene followed by elimination of N2. Compared to previously reported Cu-catalyzed gem-difluoroolefination of diazo compounds with TMSCF3, which possesses a narrow substrate scope due to a demanding requirement on the reactivity of diazo compounds and in-situ-generated CuCF3, this transition-metal-free protocol affords a general and efficient approach to various disubstituted 1,1-difluoroalkenes, including difluoroacrylates, diaryldifluoroolefins, as well as arylalkyldifluoroolefins. In view of the ready availability of diazo compounds and difluorocarbene reagents and versatile transformations of 1,1-difluoroalkenes, this new gem-difluoroolefination method is expected to find wide applications in organic synthesis.